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Computing the stationary distributions of a continuous-time Markov chain (CTMC) involves solving a set of linear equations. In most cases of interest, the number of equations is infinite or too large, and the equations cannot be solved analytically or numerically. Several approximation schemes overcome this issue by truncating the state space to a manageable size. In this review, we first give a comprehensive theoretical account of the stationary distributions and their relation to the long-term behaviour of CTMCs that is readily accessible to non-experts and free of irreducibility assumptions made in standard texts. We then review truncation-based approximation schemes for CTMCs with infinite state spaces paying particular attention to the schemes' convergence and the errors they introduce, and we illustrate their performance with an example of a stochastic reaction network of relevance in biology and chemistry. We conclude by discussing computational trade-offs associated with error control and several open questions.
90C05, stochastic reaction networks, q-bio.PE, Molecular Networks (q-bio.MN), Numerical & Computational Mathematics, FOS: Physical sciences, math.PR, ergodic distributions, 510, 90C90 (Secondary), chemical master equation, 0102 Applied Mathematics, Linear programming, Computational methods in Markov chains, FOS: Mathematics, 60J22, Quantitative Biology - Molecular Networks, 60J27 (Primary), cond-mat.stat-mech, Quantitative Biology - Populations and Evolution, Mathematics - Optimization and Control, Condensed Matter - Statistical Mechanics, boundedness in probability, math.OC, censored chain, Statistical Mechanics (cond-mat.stat-mech), Probability (math.PR), reducible Markov chains, Populations and Evolution (q-bio.PE), q-bio.MN, linear programming, error bounds, level-dependent quasi-birth-death processes, finite state projection algorithm, 0906 Electrical and Electronic Engineering, Applications of mathematical programming, Optimization and Control (math.OC), FOS: Biological sciences, Foster-Lyapunov criteria, 65C40, 60J27 (Primary), 60J22, 65C40, 90C05, 90C90 (Secondary), Numerical analysis or methods applied to Markov chains, optimal approximations, truncation-and-augmentation scheme, Mathematics - Probability, Continuous-time Markov processes on discrete state spaces
90C05, stochastic reaction networks, q-bio.PE, Molecular Networks (q-bio.MN), Numerical & Computational Mathematics, FOS: Physical sciences, math.PR, ergodic distributions, 510, 90C90 (Secondary), chemical master equation, 0102 Applied Mathematics, Linear programming, Computational methods in Markov chains, FOS: Mathematics, 60J22, Quantitative Biology - Molecular Networks, 60J27 (Primary), cond-mat.stat-mech, Quantitative Biology - Populations and Evolution, Mathematics - Optimization and Control, Condensed Matter - Statistical Mechanics, boundedness in probability, math.OC, censored chain, Statistical Mechanics (cond-mat.stat-mech), Probability (math.PR), reducible Markov chains, Populations and Evolution (q-bio.PE), q-bio.MN, linear programming, error bounds, level-dependent quasi-birth-death processes, finite state projection algorithm, 0906 Electrical and Electronic Engineering, Applications of mathematical programming, Optimization and Control (math.OC), FOS: Biological sciences, Foster-Lyapunov criteria, 65C40, 60J27 (Primary), 60J22, 65C40, 90C05, 90C90 (Secondary), Numerical analysis or methods applied to Markov chains, optimal approximations, truncation-and-augmentation scheme, Mathematics - Probability, Continuous-time Markov processes on discrete state spaces
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