The recently started European Training Network (ETN) RESCUE advances scientific competences in the demanding and mutually dependent aspects of nano-electronic systems design, i.e. reliability, security and quality, as well as related electronic design automation tools. Second, it provides early-stage researchers with innovative cross-sectoral training in the involved disciplines and beyond, preparing them to face today’s and future challenges in nano-electronics design. Furthermore, they are also trained to be innovative, creative, and more important – will have an entrepreneurial mentality. The latter will help to compile ideas into products and services for economic and social benefits and creates qualified workforce and knowledge for the industry. The consortium consists of leading European research groups competent to tackle the interdependent challenges in a holistic manner, and is excellently balanced in terms of academic and industrial training and research facilities.