With the uptaking of virtualization technologies and the growing usage of public cloud infrastructures, an ever larger number of applications run outside of the traditional enterprise's perimeter, and require new security paradigms that fit the typical agility and elasticity of cloud models in service creation and management. Though some recent proposals have integrated security appliances in the logical application topology, we argue that this approach is sub-optimal. Indeed, we believe that embedding security agents in virtualization containers and delegating the control logic to the software orchestrator provides a much more effective, flexible, and scalable solution to the problem. In this paper, we motivate our mindset and outline a novel framework for assessing cyber-threats of virtualized applications and services. We also review existing technologies that build the foundation of our proposal, which we are going to develop in the context of a joint research project.