Downloads provided by UsageCounts
Several machine learning techniques have been applied for finding multi-loci associations among Single Nucleotide Polymorphisms (SNPs) and a disease. In this paper it is investigated whether Self Organizing Maps (SOMs) can generate clusters associated with a disease based on the genetic patterns of subjects. A batch categorical SOM that can handle missing data was used on Genome Wide Association (GWA) data on Multiple Sclerosis (MS). The association of the clusters generated with the disease were initially tested using the Pearson's chi square test and then the weights of the top clusters were used for investigating for SNP patterns. The results of the analyses reveal statistically significant associations between the generated clusters and the disease, indicating that SOMs can be used for multi-loci associations.
Genome-wide association, Learning systems, Bioinformatics, Missing data, SNP, Single nucleotide polymorphisms, Genetic patterns, GWA, Clustering, Multiple sclerosis, Machine learning techniques, Multi-loci Association Testing, Chi-square tests, Self Organizing Map, Genetic studies, Self organizing maps
Genome-wide association, Learning systems, Bioinformatics, Missing data, SNP, Single nucleotide polymorphisms, Genetic patterns, GWA, Clustering, Multiple sclerosis, Machine learning techniques, Multi-loci Association Testing, Chi-square tests, Self Organizing Map, Genetic studies, Self organizing maps
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 1 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
| views | 3 | |
| downloads | 11 |

Views provided by UsageCounts
Downloads provided by UsageCounts