Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
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Heller, Gabriella T.; Aprile, Francesco A.; Michaels, Thomas C. T.; Limbocker, Ryan; Perni, Michele; Ruggeri, Francesco Simone; Mannini, Benedetta; +9 Authors
Heller, Gabriella T.; Aprile, Francesco A.; Michaels, Thomas C. T.; Limbocker, Ryan; Perni, Michele; Ruggeri, Francesco Simone; Mannini, Benedetta; Löhr, Thomas; Bonomi, Massimiliano; Camilloni, Carlo; De Simone, Alfonso; Felli, Isabella C.; Pierattelli, Roberta; Knowles, Tuomas P. J.; Dobson, Christopher M.; Vendruscolo, Michele;
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
A small molecule binds to a disordered protein in its monomeric form, preventing its aggregation linked to Alzheimer’s disease.
Italy, Italy, Italy, United Kingdom, Italy, France
- French National Centre for Scientific Research France
- Department of Chemistry Switzerland
- Institut Pasteur France
- Imperial College London United Kingdom
- Harvard University Press United States
Amyloid beta-Peptides, Alzheimer Disease, Drug Discovery, biophysics; NMR; IDP, Humans, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Hydrophobic and Hydrophilic Interactions, Research Articles, Peptide Fragments
Amyloid beta-Peptides, Alzheimer Disease, Drug Discovery, biophysics; NMR; IDP, Humans, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Hydrophobic and Hydrophilic Interactions, Research Articles, Peptide Fragments
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selected citations
Citations provided by BIP!
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 155
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