While much attention has been paid to European policy arrangements in individual policy fields, European intersectoral policy coordination has been mostly an overlooked phenomenon, especially within the sectors of education and employment. Thus, in the introductory paper for this Special Issue, we offer a contemporary discussion of European intersectoral policy coordination. We firstly review the literature on intersectoral policy coordination, and secondly look at the application of concepts related to intersectoral policy coordination to supranational arrangements, especially the European Union. We then employ the concept of boundary-spanning policy regime and the related ‘I’ framework (issues, ideas, interests, and institutions) to discuss the individual pieces’ contributions. This serves to explore the strength of the intersectoral perspective when analysing European policy coordination in education and employment. We conclude with a discussion of the strengths and limitations of this approach and offer a research agenda to study supranational intersectoral policy coordination (in education and employment).