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Paraoxonase-1 and clopidogrel efficacy

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2011 France English Publisher:Springer Science and Business Media LLCJournal:Nature Medicine, volume 17, pages 1,040-1,041 (issn: 1078-8956, eissn: 1546-170X, Copyright policy )
Authors: Dansette, Patrick; Rosi, Julien; Bertho, Gildas; Mansuy, Daniel;

doi: 10.1038/nm.2436

pmid: 21900914

Paraoxonase-1 and clopidogrel efficacy

Abstract

Clopidogrel active thiol metabolite is formed through 1) a cytochrome P450 (CYP dependent oxidation to a thiolactone : 2-oxoclopidogrel. Then a second CYP dependent oxidation to a sulfenic acid which is reduced by excess glutathione to the active cis -thiol-acid. The 2-oxoclopidogrel is hydrolyzed by paraoxonase PON 1 into an inactive isomer the endo thiol-acid. Thus PON-1 is not involved in the pharmalogical activation of clopidogrel.

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France
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Keywords

[SDV] Life Sciences [q-bio], Ticlopidine, Aryldialkylphosphatase, Humans, Coronary Disease, Stents, Platelet Aggregation Inhibitors

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
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54
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5
12
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