Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation
Copyright policy )Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation
Alterations in Notch signaling are involved in chronic lymphocytic leukemia (CLL) pathogenesis, a hematological disease characterized by the accumulation of CD19+/CD5+ B cells resistant to apoptosis. We previously reported that constitutive Notch1/2 activation contributes to apoptosis resistance of CLL cells.1 Furthermore, a NOTCH1 PEST domain mutation, resulting in a truncated protein more stable and active than wild-type (WT) protein, has recently emerged as a recurrent genetic lesion in CLL patients with adverse prognosis and poor outcome.2, 3 Despite the progress achieved on the role of NOTCH1 mutations in CLL outcome, little is known regarding their role in CLL cell biology. There is evidence that NOTCH1 mutation stabilizes Notch1 signaling in CLL cells,4 but the molecular mechanisms underlying this effect remain to be defined.
- University of Perugia Italy
- Sapienza University of Rome Italy
- Roma Tre University Italy
- University of L'Aquila Italy
- University of Chieti-Pescara Italy
Glycogen Synthase Kinase 3 beta, Gene Expression Regulation, Leukemic, Alleles; Casein Kinase II; Gene Frequency; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Receptor, Notch1; Gene Expression Regulation, Leukemic; Mutation; Hematology; Cancer Research; Anesthesiology and Pain Medicine; Medicine (all), Leukemia, Lymphocytic, Chronic, B-Cell, Protein Structure, Tertiary, Glycogen Synthase Kinase 3, Phosphatidylinositol 3-Kinases, Gene Frequency, Mutation, Humans, Phosphorylation, Receptor, Notch1, Casein Kinase II, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, chronic lymphocytic leukemia, NOTCH1 mutation, phosphorylation, cell survival, Alleles, Phosphoinositide-3 Kinase Inhibitors
Glycogen Synthase Kinase 3 beta, Gene Expression Regulation, Leukemic, Alleles; Casein Kinase II; Gene Frequency; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Receptor, Notch1; Gene Expression Regulation, Leukemic; Mutation; Hematology; Cancer Research; Anesthesiology and Pain Medicine; Medicine (all), Leukemia, Lymphocytic, Chronic, B-Cell, Protein Structure, Tertiary, Glycogen Synthase Kinase 3, Phosphatidylinositol 3-Kinases, Gene Frequency, Mutation, Humans, Phosphorylation, Receptor, Notch1, Casein Kinase II, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, chronic lymphocytic leukemia, NOTCH1 mutation, phosphorylation, cell survival, Alleles, Phosphoinositide-3 Kinase Inhibitors
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