AbstractSeveral regions worldwide have seen significant trends in anthropogenic aerosol emissions during the period of detailed satellite observations since 2001. Over Europe (EUR) and North America (NAM) there were strong declines, over China increases then declines and over India, strong increases. Regional trends in model‐simulated aerosol optical depth (AOD) and cloud radiative effects in both the Fifth and Sixth Coupled Model Intercomparison Projects (CMIP5 and CMIP6) are broadly consistent with the ones from satellite retrievals in most parts of EUR, NAM and India. CMIP6 models better match satellite‐derived AOD trend in western NAM (increasing) and eastern China (decreasing), where CMIP5 models failed, pointing to improved anthropogenic aerosol emissions. Drop concentration trends in both observations and models qualitatively match AOD trends. The result for solar cloud radiative effect in models, however, is due to compensating errors: Models fail to reproduce observed liquid water path trends and show, in turn, opposite trends in cloud fraction.