Anti-inflammatory and cytotoxic withanolides from Physalis minima
Copyright policy )Anti-inflammatory and cytotoxic withanolides from Physalis minima
Six undescribed withanolides were isolated and characterized during the investigation of anti-inflammatory and cytotoxic constituents from the whole plants of Physalis minima L. Their structures were elucidated by extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR), and their anti-inflammatory and cytotoxic activities were evaluated in vitro. All the compounds exhibited anti-inflammatory ability via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. Moderate cytotoxic activities against A549 lung adenocarcinoma cells, SMMC-7721 hepatic carcinoma cells and MCF-7 breast cancer cells with IC50 values in the range of 40.01-82.17 μM were observed for these withanolides.
- Jiangxi University of Traditional Chinese Medicine China (People's Republic of)
- University of Cologne Germany
- University Hospital Cologne Germany
- Soochow University China (People's Republic of)
- University of Mississippi United States
Lipopolysaccharides, Dose-Response Relationship, Drug, Physalis, Cell Survival, Plant Extracts, Anti-Inflammatory Agents, Molecular Conformation, Biodiversity, Nitric Oxide, Antineoplastic Agents, Phytogenic, Mice, Structure-Activity Relationship, RAW 264.7 Cells, Cell Line, Tumor, Animals, Humans, Drug Screening Assays, Antitumor, Withanolides, Taxonomy, Cell Proliferation
Lipopolysaccharides, Dose-Response Relationship, Drug, Physalis, Cell Survival, Plant Extracts, Anti-Inflammatory Agents, Molecular Conformation, Biodiversity, Nitric Oxide, Antineoplastic Agents, Phytogenic, Mice, Structure-Activity Relationship, RAW 264.7 Cells, Cell Line, Tumor, Animals, Humans, Drug Screening Assays, Antitumor, Withanolides, Taxonomy, Cell Proliferation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).38 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!