Asphodosides A-E, anti-MRSA metabolites from Asphodelus microcarpus

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2014 English Publisher:Elsevier BVJournal:Phytochemistry, volume 105, pages 79-84 (issn: 0031-9422,

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Authors: Ghoneim, Mohammed M.; Elokely, Khaled M.; El-Hela, Atef A.; Mohammad, Abd-Elsalam I.; Jacob, Melissa; Radwan, Mohamed M.; Doerksen, Robert J.; +2 Authors

doi: 10.1016/j.phytochem.2014.06.011

pmid: 25034614

pmc: PMC4883109

Asphodosides A-E, anti-MRSA metabolites from Asphodelus microcarpus

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Abstract

Bioassay guided fractionation of the ethanolic extract of Asphodelus microcarpus Salzm. et Viv. (Xanthorrhoeaceae or Asphodelaceae) resulted in isolation of five compounds identified as asphodosides A-E (1-5). Compounds 2-4 showed activity against methicillin resistant Staphylococcus aureus (MRSA) with IC50 values of 1.62, 7.0 and 9.0μg/mL, respectively. They also exhibited activity against Staphylococcus aureus (non-MRSA) with IC50 values of 1.0, 3.4 and 2.2μg/mL, respectively. The structure elucidation of isolated metabolites was carried out using spectroscopic data (1D and 2D NMR), optical rotation and both experimental and calculated electronic circular dichroism (ECD).

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Keywords

Methicillin-Resistant Staphylococcus aureus, Molecular Structure, Circular Dichroism, Biodiversity, Microbial Sensitivity Tests, Heterocyclic Compounds, 4 or More Rings, Anti-Bacterial Agents, Drug Resistance, Bacterial, Liliaceae, Nuclear Magnetic Resonance, Biomolecular, Taxonomy

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