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Über den Zusammenhang zwischen Digitalis- und Kalziumwirkung

Authors: Loewi, O.;

Über den Zusammenhang zwischen Digitalis- und Kalziumwirkung

Abstract

Es wurde untersucht, ob auch die bisher noch nicht daraufhin untersuchten Strophanthinwirkungen als Kalziumwirkungen aufzufassen sind. 1. Der negativ-dromotrope Digitalisstillstand ist Ausdruck einer gesteigerten Kalziumwirkung; er wird durch Verminderung des Kalziumgehaltes der Ringerlosung behoben. 2. Der sogenannte negativ-inotrope Digitalisstillstand ist Folge spezifisch gesteigerter Dehnbarkeit bei gleichzeitig schwacher Kontrakturwirkung. Letztere hindert das Zustandekommen normaler systolischer Kontraktionen. Auch dieser Stillstand wird durch Herabminderung des Kalziumgehaltes der Ringerlosung behoben. Die Steigerung der Dehnbarkeit last sich auser durch Digitalis auch durch Speisung mit hohen Kalziumkonzentrationen herstellen. 3. Im Stadium vorgeruckter Digitaliswirkung fuhrt Steigerung des Kaliumgehaltes der Ringerlosung zu Kontraktur. In ganz analoger Weise wirkt Kaliumsteigerung auch ohne Anwendung von Digitalis bei bloser Gegenwart hoher Kalziumkonzentrationen kontrakturierend. Diese Kontrakturwirkung ist etwas ganz anderes als die Kalziumkontrakturwirkung: letztere wird durch Steigerung des Innendruckes ganz oder teilweise behoben, ausert sich daher am besten bei entleertem Herzen; die Kaliumkontraktur dagegen wird durch Drucksteigerung gefordert, durch Druckverminderung — Entleerung des Herzens — gehemmt.

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citations
The total number of citations received by all articles of the researcher of interest.
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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