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Advanced Intelligent Systems
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Advanced Intelligent Systems
Article . 2025 . Peer-reviewed
ETH Zürich Research Collection
Article . 2025
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Analysis of the Navigation of Magnetic Microrobots through Cerebral Bifurcations for Targeted Drug Delivery

Authors: Pedro G. Alves; Maria Pinto; Rosa Moreira; Derick Sivakumaran; Fabian Landers; Maria Guix; Bradley J. Nelson; +4 Authors

Analysis of the Navigation of Magnetic Microrobots through Cerebral Bifurcations for Targeted Drug Delivery

Abstract

Local administration of thrombolytics in ischemic stroke could accelerate clot lysis and the ensuing reperfusion while minimizing the side effects of systemic administration. Medical microrobots could be injected into the bloodstream and magnetically navigated to the clot for administering the drugs directly to the target. The magnetic manipulation that is required to navigate medical microrobots depends on various parameters such as the microrobots size, the blood velocity, and the imposed magnetic field gradients. Numerical simulation was used to study the motion of magnetically controlled microrobots flowing through representative cerebral bifurcations, for predicting the magnetic gradients required to navigate the microrobots from the injection point until the target location. Upon thorough validation of the model against several independent analytical and experimental results, the model was used to generate maps and predictive equations providing quantitative information on the required magnetic gradients, for different scenarios. The developed maps and predictive equations are crucial to inform the design, operation, and optimization of magnetic navigation systems for healthcare applications.

Country
Switzerland
Keywords

drug deliveries, numerical simulations, blood flow simulations, Targeted Drug Delivery, blood flow simulations; cerebral bifurcations; drug deliveries; magnetic manipulations; microrobots; numerical simulations, cerebral bifurcations, magnetic manipulations, microrobots, Magnetic Microrobots, Cerebral Bifurcations

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    3
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Top 10%
Average
Average
Green
gold