Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy.
Copyright policy )Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy.
Sarcoidosis has been reported to be associated with the HLA genes, in particular DQB1.High resolution DQB 1 of 103 sarcoidosis patients was obtained by sequence-based typing; low resolution HLA-A/B/DRB 1 typing was performed by serological and molecular methods. Small fiber neuropathy (SFN) was established by thermal threshold testing.Sixty-seven patients suffered from SFN (SFN+), in 36 patients SFN was absent (SFN-). Comparing HLA DQB 1 typings of SFN+ patients, SFN- patients and control individuals revealed a significant increase of the allele DQB 1 0602 in SFN+ patients compared to controls.This association might be correlated with a severe course of the disease.
- Maastricht University Netherlands
Adult, Genetic Markers, Male, Sarcoidosis, DNA, Linkage Disequilibrium, Phenotype, Autonomic Nervous System Diseases, Gene Frequency, HLA-DQ Antigens, Disease Progression, HLA-DQ beta-Chains, Humans, Female, Alleles, Retrospective Studies
Adult, Genetic Markers, Male, Sarcoidosis, DNA, Linkage Disequilibrium, Phenotype, Autonomic Nervous System Diseases, Gene Frequency, HLA-DQ Antigens, Disease Progression, HLA-DQ beta-Chains, Humans, Female, Alleles, Retrospective Studies
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