Дисертація присвячена виявленню впливу поліморфізму генів інгібіторів (K121Q гена ENPP1 і Т134967G гена АNКН) та активаторів (А69314G гена ТNАР) кальцифікації на розвиток гострого коронарного синдрому (ГКС). Виявлено, що існує зв'язок між ГКС і поліморфними варіантами генів TNAР (А69314G) і АNКН (Т134967G) в українській популяції. Ризик ГКС у носіїв мінорного алеля для А69314G поліморфізму в 2,2, а для T134967G – у 1,9 раза вищий, ніж у гомозигот за основним алелем. З’ясовано, що ризик виникнення ГКС в осіб чоловічої статі носіїв мінорного алеля (А69314G поліморфізм гена TNAР) у 2,19 раза вищий, ніж у гомозигот з А/А генотипом. Доведено асоціацію досліджуваних поліморфізмів з деякими факторами ризику ГКС (ІМТ, паління, порушення ліпопротеїнового обміну та коагуляції крові). Диссертация посвящена выявлению влияния полиморфизма генов ингибиторов (K121Q гена ENPP1 и Т134967G гена АNКН) и активаторов (А69314G гена ТNАР) кальцификации на развитие острого коронарного синдрома (ОКС). Выявлено, что существует связь между ОКС и полиморфными вариантами генов TNAР (А69314G) и АNКН (Т134967G) в украинской популяции. Риск ОКС у носителей минорного алеля для А69314G полиморфизма в 2,2, а для T134967G – в 1,9 раза выше, чем у гомозигот по основному алелю. Установлено, что риск развития ОКС у лиц мужского пола носителей минорного алеля (А69314G полиморфизм гена TNAР), в 2,19 раза выше, чем у гомозигот с А/А генотипом. Доказана ассоциация исследуемых полиморфизмов с некоторыми факторами риска ОКС (ИМТ, курение, нарушения липопротеинового обмена и коагуляции крови). Thesis is devoted to the revealing the influence of the polymorphism of genes inhibitors (K121Q of gene ENPP1 and Т134967G of gene АNКН) and activators (А69314G of gene ТNАР) of calcification on the development of acute coronary syndrome. It is established the frequency of the alleles and genotypes according to the K121Q polymorphism of gene ENPP1, Т134967G polymorphism of gene АNКН and А69314G polymorphism of gene ТNАР in the Ukrainian population. It is revealed that there exists a connection between acute coronary syndrome and polymorphic variants of ТNАР (А69314G) and АNКН (Т134967G) genes. The risk of ACS in the carriers of minor allele for the А69314G polymorphism is 2,2 times and for the Т134967G – 1,9 times higher than in the homozygous dominant allele. It is found out that the influence of genetic factor on the development of cardiovascular abnormality has gender aspects. So, the risk of ACS appearing in the male carriers of minor allele (according to А69314G polymorphism of gene ТNАР) is 2,19 times higher than in the homozygous A/A genotype. It is examined the relation of the studied polymorphism to some risks factors of the acute coronary syndrome, they are: arterial hypertension, smoking, obesity, hypercoagulability, diabetes mellitus, dislipidemy of atherogenic character. The association of the studied polymorphisms with the BMI is proved. In the patients with the normal BMI, who are carriers of the minor allele, the acute coronary syndrome appears 3,9 times for the K121Q polymorphism of gene ENPP1 and 3,1 times for the Т134967G polymorphism of gene АNКН more often than in the homozygous dominant allele. The risk of the development of the ACS in the patients with the obesity (BMI ≥ 25 кг/м2), carriers of the minor allele А/G + G/G according to the А69314G polymorphism of gene ТNАР is almost 2,9 times higher than in homozygous according to the main allele A/A. Among the patients with the BMI≥ 25 кг/м2 with genotype K/K (K121Q polymorphism of gene ENPP1) acute coronary syndrome appears definitely more often than in the individuals with BMI < 25 кг/м2. The connection of the studied polymorphism with such ACS risk factor as smoking is established. The risk of appearing of the ACS in the smokers carriers of the minor allele (A/G + G/G) according to the А69314G polymorphism of gene ТNАР is 3,4 times higher than in the homozygous dominant allele. In the individuals with the T/G + G/G genotype according to Т134967G polymorphism of gene АNКН comparing to those, who do not smoke, the risk of appearing ACS is 2,1 times higher than in the individuals with T/T genotype. In the individuals with K/K genotype (K121Q polymorphism of gene ENPP1) who smoke, ACS appears definitely more often. Polymorphic variants of some studied genes are related to the lipoprotein metabolic imbalance and blood coagulation in the patient with ACS. In homozygous dominant 20 alleles (K121Q polymorphism of gene ENPP1) the index of fibrinolytic activity, the level of CH-LPLD and index of atheroginicity are definitely higher than in the carriers of other genotypes. The influence of the Т134967G polymorphism of gene АNКН on some characteristics of ACS is revealed. Statistically accurate difference about the distribution of genotypes according to the polymorphism in patients, who has suffered from the ACS without and with sequelae, is settled. Thus, the allele polymorphism of genes inhibitors and activators of calcification is an important factor in hereditary susceptibility to the sclerotic arteria involvement and their sequelae, especially the acute coronary syndrome. Deepening of knowledge on the genetic constituent of the atherosclerotic process can become the new stage in the formation of modernmethods of prognosis, prevention, diagnostication and pathogenetic treatment of atherosclerosis and its sequelae.