In this study, the fragmentation production cross-sections of heavy residual nuclides in the reactions 238 U (1 A GeV ) + p and p (1.2 GeV ) + 232 Th were calculated and the production of more than 370 different isotopes for this incident reactions was presented. The calculations were made by using the Cascade-Exciton Model including pre-equilibrium effect, the Intranuclear Cascade Model, the empirical and the semi-empirical parametrization. The results of the cross-sections obtained were compared with available experimental data and examined the relation between each other. It is seen that the precision of this models to estimate residue production cross-sections is still far from the performance required for technical applications and this incident model should be improved to obtain a deeper understanding of the reaction mechanisms involved in the production of isotopes.