Association between age at onset of multiple sclerosis and vitamin D level–related factors
Copyright policy )Association between age at onset of multiple sclerosis and vitamin D level–related factors
To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.This cross-sectional study included 1161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.
- University of Copenhagen Denmark
- Rigshospitalet Denmark
- Copenhagen University Hospital Denmark
- University of Copenhagen Denmark
- Danish Multiple Sclerosis Center Denmark
Adult, Male, Multiple Sclerosis, Sunbathing, Middle Aged, Research Support, Vitamin D Deficiency, Young Adult, Cross-Sectional Studies, Risk Factors, Surveys and Questionnaires, Journal Article, Humans, Female, Age of Onset, Vitamin D, Non-U.S. Gov't, Life Style, Genetic Association Studies, HLA-DRB1 Chains
Adult, Male, Multiple Sclerosis, Sunbathing, Middle Aged, Research Support, Vitamin D Deficiency, Young Adult, Cross-Sectional Studies, Risk Factors, Surveys and Questionnaires, Journal Article, Humans, Female, Age of Onset, Vitamin D, Non-U.S. Gov't, Life Style, Genetic Association Studies, HLA-DRB1 Chains
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).26 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!