Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer
Copyright policy )Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer
The purpose of the study was to explore the significance of FGFR4 protein expression in colorectal cancer. Immunohistochemistry showed 46.8% (148/316) tumors positive for FGFR4 and 7.3% (23/316) for adjacent normal specimens. FGFR4 positivity was correlated with shortened disease free survival (DFS) and overall survival (OS). Multivariate analysis revealed that FGFR4 was an independent prognostic factor. FGFR4 silencing markedly reduced the migration and invasion capacity of colorectal cancer cell lines. These results suggest FGFR4 is a potential prognostic and therapeutic marker for colorectal cancer.
- Shandong Women’s University China (People's Republic of)
- Jinan Central Hospital China (People's Republic of)
Male, Gene Expression, Kaplan-Meier Estimate, Middle Aged, Prognosis, Cell Movement, Cell Line, Tumor, Gene Knockdown Techniques, Biomarkers, Tumor, Humans, Female, Receptor, Fibroblast Growth Factor, Type 4, Colorectal Neoplasms, Aged, Proportional Hazards Models
Male, Gene Expression, Kaplan-Meier Estimate, Middle Aged, Prognosis, Cell Movement, Cell Line, Tumor, Gene Knockdown Techniques, Biomarkers, Tumor, Humans, Female, Receptor, Fibroblast Growth Factor, Type 4, Colorectal Neoplasms, Aged, Proportional Hazards Models
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).14 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!