Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk
Copyright policy )Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk
To investigate the association between occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines and diesel and bladder cancer risk and the modification by smoking and metabolic polymorphisms, have we recruited 200 cases and 385 population controls. The adjusted OR of bladder cancer was 5.75 (95%CI 2.09-15.83) comparing the highest tertile of the cumulative probability of occupational exposure to aromatic amines with no occupational exposure. A possible interaction between occupational exposures to aromatic amines and smoking was found. The increased ORs of GSTM1, GSTT1, NAT2 and SULT1A1 among those ever occupational exposed was explored by estimating the false-positive report probability. We confirm that occupational exposure to aromatic amines is associated with an increase in bladder cancer risk.
- University of Birmingham United Kingdom
- General Motors (United States) United States
- KU Leuven Belgium
- Maastricht University Netherlands
- Katholieke Universiteit Leuven Belgium
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Arylamine N-Acetyltransferase, Smoking, Air Pollutants, Occupational, Middle Aged, Arylsulfotransferase, Risk Assessment, Urinary Bladder Neoplasms, Risk Factors, Occupational Exposure, Odds Ratio, Humans, Female, Amines, Polycyclic Aromatic Hydrocarbons, Aged, Glutathione Transferase
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Arylamine N-Acetyltransferase, Smoking, Air Pollutants, Occupational, Middle Aged, Arylsulfotransferase, Risk Assessment, Urinary Bladder Neoplasms, Risk Factors, Occupational Exposure, Odds Ratio, Humans, Female, Amines, Polycyclic Aromatic Hydrocarbons, Aged, Glutathione Transferase
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