A new species of the spongicolid genus Spongicola, S. liosomatus sp. nov. is described and illustrated based on three male specimens and one female specimen collected from off northern Blanquilla Island, Venezuela, Caribbean Sea at a depth of 135–160 m, representing the first species of the genus found in the Atlantic Ocean. It appears closest to S. levigatus Hayashi & Ogawa, 1987, S. teres Komai, 2015 and S. inflatus de Saint-Laurent & Cleva, 1981 in having reduced armature on the body and appendages. However, the unserrated ventral edge of the third pereiopods and the membranous ridges of the first and second pereiopod cutting edges, distinguish the new species from these three species as well as all other members of the genus.