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PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

descriptionPublicationkeyboard_double_arrow_right Article 04 Dec 2014 English Publisher:American Society of HematologyJournal:Blood, volume 124, pages 3,646-3,655 (issn: 0006-4971, eissn: 1528-0020, Copyright policy )
Authors: Iqbal, M; Johns, M; Cao, J; Liu, Y; Yu, S; Hyde, G; Laffan, M; +10 Authors

doi: 10.1182/blood-2014-07-588046

pmid: 25293769

pmc: PMC4256914

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

Abstract

Key PointsThis study has identified a novel mechanism by which TF expression is posttranscriptionally regulated in macrophages. The mechanism involves the control of mRNA stability by a cooperation between PARP-14 and TTP.

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Keywords

Lipopolysaccharides, Mice, Knockout, Tumor Necrosis Factor-alpha, Macrophages, RNA Stability, Thromboplastin, Mice, Gene Expression Regulation, Tristetraprolin, Animals, Poly(ADP-ribose) Polymerases, 3' Untranslated Regions

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    popularity
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
62
Top 10%
Top 10%
Top 10%
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