Mutation of a major CG methylase in rice causes genome-wide hypomethylation, dysregulated genome expression, and seedling lethality
Copyright policy )Mutation of a major CG methylase in rice causes genome-wide hypomethylation, dysregulated genome expression, and seedling lethality
Significance CG cytosine methylation ( m CG) is an important epigenetic marker present in most eukaryotic genomes that is maintained by an evolutionarily conserved DNA methyltransferase dubbed DNMT1 in mammals and MET1 in plants. Null mutation of DNMT1 or MET1 results in global loss of m CG and leads to embryonic death in mouse, inviability in human cancer cells, and wide-ranging developmental abnormality in Arabidopsis thaliana . This study characterizes global effects of null mutation of a MET1 gene in rice, a model plant for monocotyledons, through methylome, transcriptome, and small RNAome analyses. The findings of this study have implications for improving our understanding of the biological roles of cytosine methylation in monocots and, from an applied point of view, in epigenetic manipulation of cereal crops.
- Washington State University United States
- University of California, Berkeley United States
- State Key Laboratory of Plant Genomics China (People's Republic of)
- Washington State University United States
- Jilin Academy of Agricultural Sciences China (People's Republic of)
Gene Expression Profiling, Gene Expression Regulation, Developmental, Oryza, Methyltransferases, DNA Methylation, Genes, Plant, Cytosine, Open Reading Frames, Gene Expression Regulation, Plant, RNA, Plant, Seedlings, Mutation, DNA Transposable Elements, Genome, Plant, Plant Proteins
Gene Expression Profiling, Gene Expression Regulation, Developmental, Oryza, Methyltransferases, DNA Methylation, Genes, Plant, Cytosine, Open Reading Frames, Gene Expression Regulation, Plant, RNA, Plant, Seedlings, Mutation, DNA Transposable Elements, Genome, Plant, Plant Proteins
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