Considerable damage to rabbit breeding is caused by the loss of production by eating or trampling newborn rabbits by their mothers. The main reason is the weakening of the organism due to deficiency of nutrients (high quality protein) and of biologically active substances in the diet. It is relevant today to search for non-toxic and highly effective complex preventive drugs, which have a positive effect on the mineral metabolism in animal organism. The research was carried out on the farm of Kyiv region. We studied the morphological parameters of blood by standard methods and the biochemical parameters of blood using semi-automatic biochemical analyzer with standard reagent kits. The content of chemical elements in blood plasma was investigated by the method of atomic emission spectrometry with inductively coupled plasma using Optima 2100 DV device. The paper presents the research on determining the biochemical status of an organism of lactating rabbits at the prevention of microelementosis using a new experimental eco-friendly drug. The content of total protein, albumin, glucose, total calcium, inorganic phosphorus, total bilirubin, urea, creatinine, TBA-active products, iron, manganese, copper, zinc, cobalt and activity of ALT, AST, ALP, GGT and Catalase in rabbits blood in the first,15th and 30th day for the use of the biologically active additive “Huminorm plus” is determined. In rabbit blood at the use of the “Huminorm plus” with water for watering for 15th days of the experiment, the content of hemoglobin was 1,2 times higher, phosphorus inorganic was 2.2 times higher, urea was 1.3 times higher, manganese was 3.6 times higher, cobalt was 2.6 times higher, cooper was 1.2 times higher and zinc was 1.6 times higher, compared to the first day of the experiment. In rabbit blood at the use of the “Huminorm plus” with feed for 30th days of the experiment, the number of red blood cells was determined to be 7 % higher, content of hemoglobin was 1.4 times higher, total protein was 1.2 times higher, urea was 1.3 times higher, calcium was 1.4 times higher, manganese was 3.1 times higher, zinc was twice higher, iron was 2.5 times higher, cobalt was 2.5 times higher, cooper was 1.7 times higher and alkaline phosphatase activity was 1.7 times lower, compared with the first day of experience. We defined the positive influence of the prophylactic drug on the indicators of hematopoiesis, metabolism of proteins and minerals in lactating rabbits. The development of ecofriendly, non-toxic substances for the prevention of mineral disbolism among rabbits is a promising area of research.