Background and Purpose: Patient care is changing rapidly with increased complexity of care, patient volumes, and financial constraints with rising health care costs and limited reimbursements. In response, the clinical nurse leader (CNL) role was developed. No appropriate instrument exists to measure staff satisfaction with the CNL role. This study describes the development and testing of an instrument designed to measure staff satisfaction with implementation of the CNL role. Methods: The psychometric properties and factor structure of the Clinical Nurse Leader Staff Satisfaction (CNLSS) instrument was examined. Results: A 2-factor solution was discovered for the CNLSS. Cronbach’s alpha coefficients were acceptable for the subscales and instrument. Conclusion: The CNLSS is a valid and reliable instrument. Future research should focus on establishing test–retest reliability and construct validity.