Although sufficiently mature source rocks (Early Jurassic, Late Cretaceous) and suitable reservoir facies (e.g. Late Jurassic, Early-Middle Tertiary) exist in the Tarfaya Basin (TB), past exploration has yielded few oil/gas shows but no commercially producing wells. In order to better understand the HC system of the TB, an integrated basin analysis approach has been applied including numerical modeling of the source and sink areas. Key methodologies include sequence stratigraphy, thermochronology, biostratigraphy, source-to-sink analysis, geochemistry and basin modeling.. The current sequence stratigraphic interpretation is based on i) well correlation, ii) seismo-/sequence stratigraphic interpretation; iii) data from outcrop analogue. The Mesozoic to Early Cenozoic basin development includes 5 major basin stages i) Permian to Pliensbachian rift- and sag, ii) Toarcian to Cenomanian drift, iii) Turonian to Early Eocene drift with initial Atlasian deformation, iv) Middle-Late Eocene drift with major Atlasian compression; v) Late Eocene to Early Miocene drift with major Atlasian uplift and inversion. This contribution focuses on sequence stratigraphy and numerical modeling in the sink area. At least 51 3rd order sequences have been identified along a key transect in the Jurassic-recent basin fill.