
pmid: 7480185
A chemical and biological screening of 25 species of the Gentianaceae family has been undertaken. Both methanolic and dichloromethane extracts of Swertia calycina exhibited a strong antifungal activity against Cladosporium cucumerinum and Candida albicans. The compound responsible for this activity has been isolated and identified as 2-methoxy-1,4-naphthoquinone. It is the first naphthoquinone to be described in Gentianaceae species. LC-UV and LC-TSP-MS analysis of the crude extracts of Swertia calycina also allowed on-line identification of six known xanthones and secoiridoids.
Antifungal Agents/isolation & purification/pharmacology, Antifungal Agents, Plant Extracts, Iridoid Glucosides, Rwanda, Microbial Sensitivity Tests, Glucosides/isolation & purification/pharmacology, Mass Spectrometry, Pyrans/isolation & purification/pharmacology, Naphthoquinones/isolation & purification/pharmacology, Glucosides, Iridoids, Chromatography, High Pressure Liquid, Naphthoquinones, Pyrans
Antifungal Agents/isolation & purification/pharmacology, Antifungal Agents, Plant Extracts, Iridoid Glucosides, Rwanda, Microbial Sensitivity Tests, Glucosides/isolation & purification/pharmacology, Mass Spectrometry, Pyrans/isolation & purification/pharmacology, Naphthoquinones/isolation & purification/pharmacology, Glucosides, Iridoids, Chromatography, High Pressure Liquid, Naphthoquinones, Pyrans
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