The purposes of this article are (a) to describe drug search policies in nationally representative samples of schools from 1998 to 2001 and (b) to examine the association between drug searches by schools and reported drug use by students. Most schools (86%) reported searching students for cause or suspicion, while 40% of schools reported randomly searching students. The use of drug searches differed according to school characteristics. For-cause drug searches were positively associated with 8th-, 10th-, and 12th-grade students’ 12-month illicit drug use, while random drug searches were associated (positively) only with 10th-grade students’ 12-month drug use.