<p>Native people or ethnic societies that live in endemic malaria islands such as in Bangka Island and Belitung Island have used many medicinal plants to cure malaria. Leaves of <em>kesembung</em> (<em>Scaevola taccada</em> (Gaertn Roxb), roots of <em>kebentak</em> (<em>Wikstroemia androsaemofolia</em> Decne), and roots of medang <em>mencena</em> (<em>Dapniphyllum laurinum </em>(Benth) are the examples. This research was aimed to investigate the present of some biochemical compound and evaluate the antimalarial activity of ethanol extract of the plants against <em>Plasmodium falciparum</em> 3D7 in vitro. The IC50 level was determined through visual observation under microscope over 5000 of giemsa-stained erythrocytes then analyzed by probit analysis. Results showed that kebentak root ethanol extract was effective to inhibit P. falciparum 3D7 with level 0.485 µg/mL. Furthermore, the IC50 level of <em>kesembung</em> leaves and <em>medang</em> root were 44.352 µg/mL and 1486.678 µg/mL respectively. Phytochemical test result showed that <em>kebentak</em> leaf ethanol crude extract contained triterpenoid, <em>kesembung</em> root contained phenol and tannins; moreover, <em>medang</em> root contained alkaloid, saponin, and triterpenoid.</p><p><strong>How to Cite</strong></p><p>Helmi, H., Afriyansyah, B. &amp; Ekasari, W. (2016). The Effectiveness of Local Plants from Lom and Sawang Ethnics as Antimalarial Medicine. <em>Biosaintifika: Journal of Biology &amp; Biology Education</em>, 8(2), 193-200.</p><p> </p>