Association of IL-2RA and IL-2RB genes with erosive status in early rheumatoid arthritis patients (ESPOIR and RMP cohorts)
Copyright policy )Association of IL-2RA and IL-2RB genes with erosive status in early rheumatoid arthritis patients (ESPOIR and RMP cohorts)
To assess the impact of single nucleotide polymorphisms (SNPs) in IL-2RA (rs2104286) and IL-2RB (rs743777 and rs3218253) genes on the risk of erosions in rheumatoid arthritis (RA) patients.This work is derived from 2 prospective cohorts of early RA: ESPOIR (n = 439) and RMP (n = 180). The proportions of patients with erosions at baseline and 1 year according to the genotypes of IL2RA (rs2104286) or the haplotypes constructed with the 2 SNPs of IL2RB were compared in the whole population and in ACPA positive patients. A meta-analysis assessing the risk of erosion depending on the haplotypes of the 2 SNPs of IL-2RB was performed using the Mantel-Haenszel method. A multivariate model was used to assess the independent effect of the haplotypes of IL-2RB on the risk of erosions.The AC haplotype of IL-2RB carriage was significantly associated with the rate of erosions in ACPA positive patients in ESPOIR cohort (rate of erosions: AC/AC: 78% versus GC or GT/GC or GT: 44%, p = 0.001). A meta-analysis of ESPOIR and RMP cohorts confirmed that the carriage of AC haplotype was significantly associated with the rate of erosions at 1 year in the whole sample (OR[95%CI] = 1.92[1.14-3.22], p = 0.01) and in ACPA positive patients (OR[95%CI] = 3.34[1.68-6.67], p = 0.0006). A multivariate model in ESPOIR cohort demonstrated the independent effect of the carriage of the AC haplotype (6.03[1.94-18.69], p = 0.002) on the risk of erosions in ACPA+ patients.A haplotype constructed with 2 SNPs located on IL-2RB gene was associated with erosive status in early RA.
Male, [SDV]Life Sciences [q-bio], MESH: Interleukin-2 Receptor alpha Subunit, MESH: Genotype, Single nucleotid polymorphism, Arthritis, Rheumatoid, Cohort Studies, Rheumatoid, MESH: Autoantibodies, MESH: Cohort Studies, Cyclic, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, MESH: Middle Aged, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Peptides, MESH: Genetic Predisposition to Disease, Single Nucleotide, Middle Aged, IL-2RB, IL-2RA, MESH: Interleukin-2 Receptor beta Subunit, [SDV] Life Sciences [q-bio], [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Disease Progression, MESH: Disease Progression, Female, Adult, Genotype, 610, MESH: Arthritis, Peptides, Cyclic, Polymorphism, Single Nucleotide, 616, Humans, Genetic Predisposition to Disease, Rheumatoid arthritis, MESH: Polymorphism, Autoantibodies, Disease progression, MESH: Humans, Interleukin-2 Receptor alpha Subunit, MESH: Adult, MESH: Haplotypes, MESH: Male, Interleukin-2 Receptor beta Subunit, Haplotypes, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Male, [SDV]Life Sciences [q-bio], MESH: Interleukin-2 Receptor alpha Subunit, MESH: Genotype, Single nucleotid polymorphism, Arthritis, Rheumatoid, Cohort Studies, Rheumatoid, MESH: Autoantibodies, MESH: Cohort Studies, Cyclic, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, MESH: Middle Aged, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Peptides, MESH: Genetic Predisposition to Disease, Single Nucleotide, Middle Aged, IL-2RB, IL-2RA, MESH: Interleukin-2 Receptor beta Subunit, [SDV] Life Sciences [q-bio], [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Disease Progression, MESH: Disease Progression, Female, Adult, Genotype, 610, MESH: Arthritis, Peptides, Cyclic, Polymorphism, Single Nucleotide, 616, Humans, Genetic Predisposition to Disease, Rheumatoid arthritis, MESH: Polymorphism, Autoantibodies, Disease progression, MESH: Humans, Interleukin-2 Receptor alpha Subunit, MESH: Adult, MESH: Haplotypes, MESH: Male, Interleukin-2 Receptor beta Subunit, Haplotypes, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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