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Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2015 English Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - General Subjects, volume 1,850, pages 1,224-1,232 (issn: 0304-4165,

Authors: Robert Tarran; Robert Balsiger; Xiaohua Xu; Estelle Cormet-Boyaka; Prosper N. Boyaka; Jean Tyrrell;

doi: 10.1016/j.bbagen.2015.02.004 , 10.17615/d2t0-af54

pmid: 25697727

pmc: PMC4398641

Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR

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Abstract

CFTR plays a key role in maintenance of lung fluid homeostasis. Cigarette smoke decreases CFTR expression in the lung but neither the mechanisms leading to CFTR loss, nor potential ways to prevent its loss have been identified to date.

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Keywords

Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Time Factors, MAP Kinase Signaling System, Smoking, Cystic Fibrosis Transmembrane Conductance Regulator, Down-Regulation, Bronchi, Epithelial Cells, MAP Kinase Kinase Kinases, Transfection, Antioxidants, Cell Line, Smoke, Humans, RNA Interference, Proto-Oncogene Proteins c-cbl, Protein Kinase Inhibitors

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