The murine latent transforming growth factor-β binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21–22
Copyright policy )The murine latent transforming growth factor-β binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21–22
The latent transforming growth factor-beta (TGF-beta) binding protein-1 belongs to a family of matrix glycoproteins that is functionally associated with the assembly and secretion of TGF-beta. We have isolated and sequenced a murine approximately 15-kbp contig containing part of Ltbp-1 and used a mouse-hamster radiation hybrid panel to determine its chromosomal localization on distal mouse chromosome 17. This map location is syntenic to human chromosomal subband 2p21-22. Similarly, human LTBP-1 was mapped to 2p21-22 by fluorescence in situ hybridization. Like in humans, the murine Ltbp-1 gene directs the synthesis of two different transcript sizes encoding two alternatively spliced isoforms (Ltbp-1S and Ltbp-1L), which are regulated in a tissue-and stage-dependent manner. Sequence analysis and database searches further reveal that the upstream regions of both isoforms are devoid of TATA and CAAT boxes but contain other putative binding sites for several transcription factors conserved in mouse and human. The utilization of different promoters and their evolutionarily conservation further emphasize the complex regulation of Ltbp-1.
- Max Planck Society Germany
- Max Planck Institute of Biochemistry Germany
- RWTH Aachen University Germany
- Universitätsklinikum Aachen Germany
Male, Base Sequence, 5' Flanking Region, Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Chromosome Mapping, Gene Expression, Mice, Inbred Strains, DNA, Blotting, Northern, Alternative Splicing, Mice, Latent TGF-beta Binding Proteins, Chromosomes, Human, Pair 2, Animals, Humans, Protein Isoforms, Amino Acid Sequence, Carrier Proteins, In Situ Hybridization, Fluorescence
Male, Base Sequence, 5' Flanking Region, Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Chromosome Mapping, Gene Expression, Mice, Inbred Strains, DNA, Blotting, Northern, Alternative Splicing, Mice, Latent TGF-beta Binding Proteins, Chromosomes, Human, Pair 2, Animals, Humans, Protein Isoforms, Amino Acid Sequence, Carrier Proteins, In Situ Hybridization, Fluorescence
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