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Bioactivation of nitroglycerin by the East Asian variant of aldehyde dehydrogenase-2

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Aug 2009 English Publisher:Springer Science and Business Media LLCJournal:BMC Pharmacology, volume 9 (eissn: 1471-2210, Copyright policy )
Authors: Michael Russwurm; Robert Weis; Matteo Beretta; Doris Koesling; Bernd Mayer; Kurt Schmidt; Antonius C.F. Gorren; +1 Authors

doi: 10.1186/1471-2210-9-s2-a40 , 10.1186/1471-2210-9-s1-p3

Bioactivation of nitroglycerin by the East Asian variant of aldehyde dehydrogenase-2

Abstract

Background The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly reduced dehydrogenase, esterase and nitroglycerin (GTN) reductase activities [1]. The small molecule Alda-1 was reported to partly restore low acetaldehyde dehydrogenase activity of this variant [2]. In the present study we compared the wild-type enzyme (ALDH2*1) with the East Asian variant (ALDH2*2) regarding GTN bioactivation and effects of Alda-1.

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Keywords

Pharmacology, Poster Presentation, Meeting Abstract, Pharmacology (medical)

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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gold