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A molecular map of the immune response region from the major histocompatibility complex of the mouse

descriptionPublicationkeyboard_double_arrow_right Article 04 Nov 1982 United States English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 300, pages 35-42 (issn: 0028-0836, eissn: 1476-4687,

Authors: Steinmetz, M; Minard, K; Horvath, S; Mcnicholas, J; Frelinger, E; Wake, C; Long, E; +2 Authors

doi: 10.1038/300035a0

pmid: 6290895

A molecular map of the immune response region from the major histocompatibility complex of the mouse

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Abstract

A stretch of 200 kilobases (kb) of DNA from the I region of the mouse major histocompatibility complex has been cloned and characterized. It contains the genes for the biochemically defined class II proteins E alpha, E beta and A beta. DNA blot analyses suggest that the I region may contain only 6-8 class II genes. Correlation of our molecular map with the genetic map of the I region confines two of the five I subregions, I-J and I-B, to less than 3.4 kb of DNA at the 3' end of the E beta gene where a hotspot for recombination has been observed. Indeed, the I-A and I-E subregions may be contiguous. If so, the I-B and I-J subregions are not encoded in the I region between the I-A and I-E subregions.

Country

United States

Related Organizations

University of California System
United States
Stanford University
United States
California Institute of Technology
United States
University of Geneva
Switzerland
Jackson Laboratory
United States

Keywords

570, Mice, Inbred BALB C, Macromolecular Substances, Congenic Resistant Lines:, Genes:, 150, DNA, Recombinant, 610, DNA, DNA Restriction Enzymes, Biochemistry, Major Histocompatibility Complex, Mice, Strains:, Genes, Metabolism:, Histocompatibility Antigens, Animals, Cloning, Molecular, Hereditary Factors:, Plasmids

73 Research products, page 1 of 8

H-2 class II histocompatibility antigen, A-K alpha chain
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MHC class II antigen O region beta locus
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H-2 class II histocompatibility antigen, A-F alpha chain
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Uncharacterized protein
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H-2 class II histocompatibility antigen, A-D alpha chain
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MHC class II E-beta (R haplotype)
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H-2 class II histocompatibility antigen, A-D beta chain
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H2-Eb1 protein
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	564
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 0.1%
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