CREB pathway links PGE2 signaling with macrophage polarization
Copyright policy )CREB pathway links PGE2 signaling with macrophage polarization
Significance The second messenger cAMP exerts potent immunosuppressive effects on the innate immune system, in part by activating class IIa histone deacetylases, and thereby inhibiting NF-κB–dependent transcription. We found that cAMP also promotes M2 macrophage polarization by stimulating the cyclic AMP-responsive element binding (CREB)/cAMP-regulated transcriptional coactivators TORC1 pathway. In the setting of acute overnutrition, macrophage CREB inhibits the production of inflammatory mediators and contributes to the maintenance of insulin sensitivity.
- University of Pennsylvania United States
- Shanghai Tenth People's Hospital China (People's Republic of)
- The Salk Institute United States
- UNIVERSITY OF PENNSYLVANIA
- Salk Institute for Biological Studies United States
Macrophages, Kruppel-Like Transcription Factors, Cell Polarity, Dinoprostone, Kruppel-Like Factor 4, Mice, Animals, Humans, Interleukin-4, Insulin Resistance, Cyclic AMP Response Element-Binding Protein, Signal Transduction, Transcription Factors
Macrophages, Kruppel-Like Transcription Factors, Cell Polarity, Dinoprostone, Kruppel-Like Factor 4, Mice, Animals, Humans, Interleukin-4, Insulin Resistance, Cyclic AMP Response Element-Binding Protein, Signal Transduction, Transcription Factors
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