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Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer

descriptionPublicationkeyboard_double_arrow_right Article 24 Dec 2013Publisher:SAGE PublicationsJournal:Cancer Biomarkers, volume 13, pages 359-366 (issn: 1574-0153, eissn: 1875-8592,

Authors: Sangmi Kim; Robert S. Sandler; Melissa Kang; Joseph A. Galanko; Temitope O. Keku; Xiang J. Shen; Felix Araujo-Perez; +1 Authors

doi: 10.3233/cbm-130366 , 10.17615/a912-z048

pmid: 24440976

pmc: PMC4589188

Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer

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- Related research
  (31)
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Abstract

African Americans have worse outcomes in colorectal cancer (CRC) than Caucasians. We sought to determine if KRAS, BRAF and PIK3CA mutations might contribute to the racial differences in CRC outcome.

Related Organizations

University of North Carolina at Chapel Hill
United States
University of Georgia Press
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University of Maine
United States
Georgia Regents University
United States
UNC Lineberger Comprehensive Cancer Center
United States

Keywords

Male, Proto-Oncogene Proteins B-raf, Class I Phosphatidylinositol 3-Kinases, DNA Mutational Analysis, Middle Aged, Prognosis, Black or African American, Cohort Studies, Phosphatidylinositol 3-Kinases, Gene Frequency, Proto-Oncogene Proteins, Mutation, Humans, Female, Genetic Predisposition to Disease, Colorectal Neoplasms, Genetic Association Studies, Aged, Neoplasm Staging, Proportional Hazards Models

31 Research products, page 1 of 4

B-Raf serine/threonine-protein
2017IsRelatedTo
PR371 c-K-ras oncogene
2017IsRelatedTo
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b
2017IsRelatedTo
K-ras p21 protein
2017IsRelatedTo
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform variant
2017IsRelatedTo
UBE2L3/KRAS fusion protein
2017IsRelatedTo
Serine/threonine-protein kinase B-raf
2017IsRelatedTo
PI3 kinase
2017IsRelatedTo
K-ras
2017IsRelatedTo
BRAF protein
2017IsRelatedTo

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	32
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%