The geological basement of the Gawler Craton in South Australia is a stable crystalline basement province comprising extensive deformed Archaean, Palaeo- and Meso- Proterozoic suites, of mainly gneiss, amphibolite and granite. The Craton is host to many historical mineral prospects and includes the world class Olympic Dam Cu-Au-U deposit. An extensive surficial and sedimentary cover, limits our understanding of the Craton’s geology and prospectivity is in comparison with other Australian Cratons. A lack of exposure of fresh outcrop results from the combination of deep weathering, which produces a thick in-situ regolith and the presence of significant transported alluvial and colluvial sheetflow deposits, ferruginous consolidated aeolian sands, evaporites and alluvial channel deposits. The area also has an extensive cover of laterite, calcrete and silcrete with minor weathered saprolite and very limited fresh rock outcrop. This geologic and regolith setting results in a subdued geomorphic province dominated by major low relief perennial drainage and palaeodrainage systems and dune landforms. Recent hi-resolution airborne geophysical surveys have highlighted the continuing prospectivity of the region leading for example to new mines such as the Challenger Au deposit. However, the production of maps useful for continued mineral exploration in such a regolith-dominated terrain is problematic. New regolith-landform maps are being used along with a variety of geophysical datasets to develop GIS ingredient datasets and layers, which reveal favourable sites and vectors for mineral prospectivity. In this study we evaluate the use of Hyperion satellite hyperspectral data for regolith-landform map production and determine the benefits derived from the data for geological interpretation in an area adjacent to gold mineralisation at the Tarcoola minesite. Mineralisation is associated with strong kaolin, sericite, and goethite alteration of metasediment near a granitesediment contact. Alteration minerals include locally abundant copper, lead, zinc and arsenic sulphides. Mobile indicator elements in the regolith, associated with mineralisation, can be traced to their origin, which may provide clues to the detection of concealed ore bodies. The procedures by which images are acquired, processed and interpreted are highlighted with the Hyperion data used to produce a comprehensive regolithlandform map. ENVI minimum noise fractionation (MNF) and mixture tuned matched filtering (MTMF) imaging processes has allowed the discrimination of favourable alteration systems and potential mineralisation sites.