The present study was undertaken with the objective of influence of various animal factors like parity, stage of lactation, production level and season of calving on milk somatic cell count (SCC) in Jersey crossbred cows reared under hot-humid climatic condition. Total 366 quarter wise morning milk samples were collected aseptically from the experimental cows maintained at cattle yard, ICAR- National Dairy Research Institute, Eastern Regional Station, Kalyani, West Bengal and subjected to microscopic method of somatic cell count. The estimated overall arithmetical mean (±SE) of SCC (logarithmic) was 5.377 ± 0.039. There was significant (P<0.01) effect of all the animal factors and season of calving on Log10SCC. The SCC was significantly (P<0.05) higher in cows of later parities and late stage of lactation. Medium milk producer animals had significant (P<0.05) lower mean SCC as compared to low and high milk producers. The SCC level was significantly (P<0.05) higher in cows calved during the summer season followed by cows calved in rainy and winter season. It can be concluded that the animal factors like parity, lactation stage, production level and season of calving has noteworthy effect on milk SCC level in crossbred cows under hot-humid climatic condition and therefore, these factors can be taken into account while selecting dairy animals accompanied by SCC can be used as routine tests to achieve the best strategy for the treatment and prevention of intra-mammary infections (IMI) in dairy cows.