Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface
Copyright policy )Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface
In eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational modification in the lumen of the endoplasmic reticulum (ER). After anchor attachment, the GPI anchor is structurally remodeled to function as a transport signal that actively triggers the delivery of GPI-APs from the ER to the plasma membrane, via the Golgi apparatus. The structure and composition of the GPI anchor confer a special mode of interaction with membranes of GPI-APs within the lumen of secretory organelles that lead them to be differentially trafficked from other secretory membrane proteins. In this review, we examine the mechanisms by which GPI-APs are selectively transported through the secretory pathway, with special focus on the recent progress made in their actively regulated export from the ER and the trans-Golgi network.
- Spanish National Research Council Spain
- University of Geneva Switzerland
- University of Seville Spain
- Department of Biochemistry Switzerland
- Hospital Universitario Virgen del Rocío Spain
Glycosylphosphatidylinositols, Proteínas ancladas a GPI, Membrane Proteins, Tráfico de membrana, p24 complex, QD415-436, 540, Endoplasmic Reticulum, Aparato de Golgi, Biochemistry, Remodelado del anclaje GPI, Retículo endoplásmico, Protein Transport, glycolipid anchor remodeling, Vía secretora, Animals, Humans, lipid-based sorting, trans-Golgi Network, ddc: ddc:540
Glycosylphosphatidylinositols, Proteínas ancladas a GPI, Membrane Proteins, Tráfico de membrana, p24 complex, QD415-436, 540, Endoplasmic Reticulum, Aparato de Golgi, Biochemistry, Remodelado del anclaje GPI, Retículo endoplásmico, Protein Transport, glycolipid anchor remodeling, Vía secretora, Animals, Humans, lipid-based sorting, trans-Golgi Network, ddc: ddc:540
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