As part of a floristic project dealing with the ferns and lycophytes from the region of Vicosa in Minas Gerais, Brazil, we present a taxonomic treatment of the Schizaeales. Seven species of Anemia occur in the region: A. hirsuta, A. hispida, A. mandioccana, A. mickelii, sp. nov., A. phyllitidis, A. raddiana, and A. tomentosa var. tomentosa. Based on morphology and field studies, we found four hybrids: A. hirsuta × A. mickelii (= A. × mexiae, hybrid nov.), A. hispida × A. mickelii (= A. × semihispida, hybrid nov.), A. hirsuta × A. phyllitidis (= A. ×semihirsuta), and A. mickelii × A. ×semihirsuta (= A. ×promiscua, hybrid nov.). Two species of Lygodium occur in the region (L. venustum and L. volubile) and their hybrid, L. ×fayae. Among the five hybrids documented here, three are reported for the first time in the literature, and two are reported for the first time in Brazil. We also present keys to species and hybrids, descriptions, illustrations, lists of examined material, and updated geographical distributions of all taxa.