The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family1
Copyright policy )The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family1
Murine MyD88, an RNA with homology both to the interleukin‐1 receptor signaling domain and to ‘death‐domains’, is rapidly upregulated during differentiation of the myeloleukemic cell line M1. We have cloned the human homologue of murine MyD88 and re‐evaluated the murine sequence. The open reading frame for both species encodes a 296 amino acid protein, which for murine MyD88 is 53 amino acids longer than originally published. Human MyD88 cDNA is encoded by 5 exons, and maps to chromosome 3p21.3‐p22 by fluorescence in situ hybridization (FISH). Overexpression of the death domain region leads to transcriptional activation of the IL‐8 promoter.
DNA, Complementary, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Gene Expression, Mice, Animals, Humans, Amino Acid Sequence, Promoter Regions, Genetic, In Situ Hybridization, Fluorescence, Adaptor Proteins, Signal Transducing, Base Sequence, Interleukin-8, Chromosome Mapping, Exons, BIOLOGIE MOLECULAIRE, Oligonucleotides, Antisense, Antigens, Differentiation, Introns, [SDV] Life Sciences [q-bio], COS Cells, Myeloid Differentiation Factor 88, Chromosomes, Human, Pair 3
DNA, Complementary, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Gene Expression, Mice, Animals, Humans, Amino Acid Sequence, Promoter Regions, Genetic, In Situ Hybridization, Fluorescence, Adaptor Proteins, Signal Transducing, Base Sequence, Interleukin-8, Chromosome Mapping, Exons, BIOLOGIE MOLECULAIRE, Oligonucleotides, Antisense, Antigens, Differentiation, Introns, [SDV] Life Sciences [q-bio], COS Cells, Myeloid Differentiation Factor 88, Chromosomes, Human, Pair 3
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