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DOGR1 and DOGR2: Two genes from Saccharomyces cerevisiae that confer 2‐deoxyglucose resistance when overexpressed

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1995 English Publisher:WileyJournal:Yeast, volume 11, pages 1,233-1,240 (issn: 0749-503X, eissn: 1097-0061,

Authors: Francisca Randez-Gil; Pascual Sanz; Amalia Blasco; Jose Antonio Prieto;

doi: 10.1002/yea.320111303

pmid: 8553694

DOGR1 and DOGR2: Two genes from Saccharomyces cerevisiae that confer 2‐deoxyglucose resistance when overexpressed

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Abstract

AbstractSaccharomyces cerevisiae contains two genes (DOGR1 and DOGR2) that are able to confer 2‐deoxyglucose resistance when they are overexpressed. These genes are very similar, sharing 92% identity at the protein level. They code for two isoenzymes with 2‐deoxyglucose‐6 phosphate (2‐DOG‐6P) phosphatase activity. These enzymes have been purified and characterized. DogR1p shows an optimum pH of 6, an optimum temperature of 30°C and a KM on 2‐DOG‐6P of 17 mM. DogR2p shows a similar optimum pH, but the optimum temperature is 40°C and it exhibits a KM on 2‐DOG‐6P of 41 mM. Both enzymes require 10 mM‐MgCl2 for maximal activity and they are inhibited by inorganic phosphate.

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Keywords

Base Sequence, Genes, Fungal, Molecular Sequence Data, Glucosephosphates, Glucose-6-Phosphate, Amino Acid Sequence, Saccharomyces cerevisiae, Deoxyglucose, Alleles

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