Electronic Health Record-Based Genome-Wide Meta-Analysis Provides New Insights on the Genetic Architecture of Non-Alcoholic Fatty Liver Disease
Copyright policy )Electronic Health Record-Based Genome-Wide Meta-Analysis Provides New Insights on the Genetic Architecture of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a complex disease linked to several chronic diseases. We aimed at identifying genetic variants associated with NAFLD and evaluating their functional consequences. We performed a genome-wide meta-analysis of 4 cohorts of electronic health record-documented NAFLD in participants of European ancestry (8,434 cases and 770,180 controls). We identify 5 potential susceptibility loci for NAFLD (located at or near GCKR, TR1B1, MAU2/TM6SF2, APOE, and PNPLA3). We also report a potentially causal effect of lower LPL expression in adipose tissue on NAFLD susceptibility and an effect of the FTO genotype on NAFLD. Positive genetic correlations between NAFLD and cardiometabolic diseases and risk factors such as body fat accumulation/distribution, lipoprotein-lipid levels, insulin resistance, and coronary artery disease and negative genetic correlations with parental lifespan, socio-economic status, and acetoacetate levels are observed. This large GWAS meta-analysis reveals insights into the genetic architecture of NAFLD.
- Université Laval Canada
- University of Tartu Estonia
- Massachusetts General Hospital United States
- Harvard University United States
- Broad Institute United States
Medicine (General), genome-wide association study, non-alcoholic fatty liver disease, lipoprotein lipase, Genetic Variation, Article, Linkage Disequilibrium, adipose tissue, Lipoprotein Lipase, electronic health records, R5-920, Phenotype, Non-alcoholic Fatty Liver Disease, Electronic Health Records, Humans, genetics, Genetic Predisposition to Disease, Obesity, Genome-Wide Association Study
Medicine (General), genome-wide association study, non-alcoholic fatty liver disease, lipoprotein lipase, Genetic Variation, Article, Linkage Disequilibrium, adipose tissue, Lipoprotein Lipase, electronic health records, R5-920, Phenotype, Non-alcoholic Fatty Liver Disease, Electronic Health Records, Humans, genetics, Genetic Predisposition to Disease, Obesity, Genome-Wide Association Study
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).145 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!