Motivated by the study of V-rings, we introduce the concept of V-category, as a Grothendieck category with the property that any simple object is injective. We present basic properties of V-categories, and we study this concept in the special case of locally finitely generated categories, for instance the category R-gr of all graded left R-modules, where R is a graded ring. We use the characterizations of V-categories in the study of graded V-rings. Since V-rings are closely related to Von Neumann regular rings (in the commutative case these classes of rings coincide), the last part of the article is devoted to graded regular rings.