Distribution of HLA‐B alleles in nasopharyngeal carcinoma patients and normal controls in Thailand
Copyright policy )Distribution of HLA‐B alleles in nasopharyngeal carcinoma patients and normal controls in Thailand
Abstract:HLA‐B frequencies in 54 unrelated nasopharyngeal carcinoma (NPC) patients and 49 healthy random controls in Thailand were investigated by direct DNA sequencing. Similar to previous reports in Chinese NPC patients, HLA‐B*4601 was observed at a greater frequency in patients (21/54 (40%)) compared to controls (7/49 (14%). An increase in HLA‐B*51012 was also demonstrated. B*51012 was present in 6/54 (11%) NPC patients but was not observed (0%) in controls. B*44032 was associated with a decreased risk. Five out of 54 (9%) NPC patients had B*44032 compared to 14/49 (29%) in the control group.
- Georgetown University United States
- Chulalongkorn University Thailand
Male, Adolescent, Carcinoma, Nasopharyngeal Neoplasms, Thailand, Epstein-Barr Virus Nuclear Antigens, Gene Frequency, Haplotypes, HLA-B Antigens, HLA-B51 Antigen, Humans, Female, Alleles, Aged
Male, Adolescent, Carcinoma, Nasopharyngeal Neoplasms, Thailand, Epstein-Barr Virus Nuclear Antigens, Gene Frequency, Haplotypes, HLA-B Antigens, HLA-B51 Antigen, Humans, Female, Alleles, Aged
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