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Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women

مرض شاغاس الخلقي: توصيات محدثة للوقاية والتشخيص والعلاج ومتابعة الأطفال حديثي الولادة والأشقاء والفتيات والنساء في سن الإنجاب والنساء الحوامل
Authors: Jaime Altcheh; Andrea Angheben; Alejandro O. Luquetti; Héctor Freilij; Manuel Segovia; Yves Carlier; Yves Carlier; +3 Authors

Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women

Abstract

En 2005, l'Organisation mondiale de la santé (OMS) a reconnu la maladie de Chagas (MC ; infection à Trypanosoma cruzi) comme une maladie tropicale négligée (MTN) [1] et l'a incluse dans le plan mondial de lutte contre les MTN [2]. La cible 3.3 des objectifs de développement durable des Nations Unies (ODD/ONU) vise à mettre fin aux épidémies de MTN d'ici 2030 [3]. La transmission de la mère à l'enfant (congénitale/connatale) est actuellement le principal mode de transmission de T. cruzi par transfusion sanguine et transplantation d'organes dans les zones exemptes de vecteurs à l'intérieur et à l'extérieur de l'Amérique latine (LA). Sur la base des récentes démonstrations que la transmission congénitale peut être évitée [4–7], l'OMS A déplacé son objectif, en 2018, du contrôle à l'élimination de la MC congénitale (cCD) (documents de référence de la feuille de route en préparation). Cet article résume les recommandations du Groupe technique de l'OMS sur la « Prévention et le contrôle de la transmission congénitale et la gestion des cas d'infections congénitales à Trypanosoma cruzi » (OMS, Département de la lutte contre les maladies tropicales négligées). Il met à jour et complète les recommandations précédemment publiées en 2011 par le Groupe Technique [8]. Ces recommandations consensuelles découlent des discussions lors des réunions techniques convoquées par l'OMS à Murcie (Espagne) les 9 et 10 octobre 2018 (II Consultation technique de l'OMS sur la lutte contre la maladie de Chagas congénitale dans les pays non endémiques et réunions spécifiques du Groupe technique).

En 2005, la Organización Mundial de la Salud (OMS) reconoció la enfermedad de Chagas (EC; infección por Trypanosoma cruzi) como una enfermedad tropical desatendida (ETD) [1] y la incluyó en el plan mundial para combatir las ETD [2]. La Meta 3.3 de los Objetivos de Desarrollo Sostenible de las Naciones Unidas (ONU/ODS) tiene como objetivo poner fin a las epidemias de ETD para 2030 [3]. La transmisión de madre a hijo (congénita/conyugal) es actualmente el principal modo de transmisión de T. cruzi a través de transfusiones de sangre y trasplantes de órganos en áreas libres de vectores dentro y fuera de América Latina (AL). Con base en demostraciones recientes de que la transmisión congénita se puede prevenir [4–7], la OMS ha cambiado su objetivo, en 2018, del control a la eliminación de la CD congénita (cCD) (documentos de referencia de la hoja de ruta en preparación). Este artículo resume las recomendaciones del Grupo Técnico de la OMS sobre "Prevención y Control de la Transmisión Congénita y Manejo de Casos de Infecciones Congénitas por Trypanosoma cruzi" (OMS, Departamento de Control de Enfermedades Tropicales Desatendidas). Actualiza y completa las recomendaciones publicadas previamente en 2011 por el Grupo Técnico [8]. Estas recomendaciones consensuadas se derivan de las discusiones en las reuniones técnicas convocadas por la OMS en Murcia (España) los días 9 y 10 de octubre de 2018 (II Consulta Técnica de la OMS sobre el Control de la Enfermedad Congénita de Chagas en países no endémicos y reuniones específicas del Grupo Técnico).

In 2005, the World Health Organization (WHO) recognized Chagas disease (CD; Trypanosoma cruzi infection) as a neglected tropical disease (NTD) [1] and included it into the global plan to combat NTDs [2]. The Target 3.3 of the United Nations Sustainable Development Goals (UN/SDG) aims at ending the epidemics of NTDs by 2030 [3]. Mother-to-child (congenital/connatal) transmission is currently the main mode of transmission of T. cruzi over blood transfusions and organ transplantations in vector-free areas within and outside Latin America (LA). Based on recent demonstrations that congenital transmission can be prevented [4–7], WHO has shifted its objective, in 2018, from control to elimination of congenital CD (cCD) (road map reference documents in preparation). This article summarizes the recommendations of the WHO Technical Group on "Prevention and Control of Congenital Transmission and Case Management of Congenital Infections with Trypanosoma cruzi" (WHO, Department of Control of Neglected Tropical Diseases). It updates and completes the recommendations previously published in 2011 by the Technical Group [8]. These consensual recommendations derive from discussions at technical meetings convened by WHO in Murcia (Spain) on 9–10 October 2018 (II WHO Technical Consultation on Control of Congenital Chagas disease in nonendemic countries, and specific meetings of the Technical Group).

في عام 2005، اعترفت منظمة الصحة العالمية (WHO) بمرض شاغاس (CD ؛ عدوى المثقبية الكروزية) كمرض مداري مهمل (NTD) [1] وأدرجته في الخطة العالمية لمكافحة الأمراض المدارية المهملة [2]. الهدف 3.3 من أهداف الأمم المتحدة للتنمية المستدامة (UN/SDG) يهدف إلى إنهاء أوبئة الأمراض المدارية الوطنية بحلول عام 2030 [3]. يعد انتقال العدوى من الأم إلى الطفل (الخلقي/الخلقي) حاليًا الطريقة الرئيسية لانتقال T. cruzi عبر عمليات نقل الدم وزرع الأعضاء في المناطق الخالية من النواقل داخل وخارج أمريكا اللاتينية (LA). استنادًا إلى الأدلة الحديثة على أنه يمكن منع انتقال العدوى الخلقية [4–7]، التي حولت هدفها، في عام 2018، من السيطرة إلى القضاء على القرص المضغوط الخلقي (cCD) (الوثائق المرجعية لخريطة الطريق قيد الإعداد). يلخص هذا المقال توصيات الفريق الفني لمنظمة الصحة العالمية بشأن "الوقاية من العدوى الخلقية بالمثقبية الكروزية ومكافحتها وإدارة حالات العدوى الخلقية بها" (منظمة الصحة العالمية، إدارة مكافحة الأمراض المدارية المهملة). وهو يقوم بتحديث وإكمال التوصيات التي نشرتها المجموعة الفنية سابقًا في عام 2011 [8]. وتستمد هذه التوصيات التوافقية من المناقشات التي جرت في الاجتماعات التقنية التي عقدتها منظمة الصحة العالمية في مورسيا (إسبانيا) في الفترة من 9 إلى 10 تشرين الأول/أكتوبر 2018 (المشاورة التقنية الثانية لمنظمة الصحة العالمية بشأن مكافحة مرض شاغاس الخلقي في البلدان غير الموبوءة، والاجتماعات المحددة للفريق التقني).

Countries
Argentina, Switzerland, Belgium
Keywords

Public Health/standards, Chagas disease, Tropical disease, Epidemiology, Infectious Disease Transmission, Epidemiology and Treatment of Chagas Disease, RC955-962, Santé publique, Pediatrics, Engineering, Pregnancy, Arctic medicine. Tropical medicine, https://purl.org/becyt/ford/3.2, Pathology, Disease, Neglected tropical diseases, Latin Americans, FOS: Philosophy, ethics and religion, Viewpoints, Chagas, Parasitic/diagnosis/prevention & control/therapy, Medicine, Female, Public Health, Public aspects of medicine, RA1-1270, Cardiology and Cardiovascular Medicine, Family medicine, Trypanosoma cruzi, Immunology, Pregnant People, 618, Delivery of Health Care/standards, Health Sciences, Humans, Chagas Disease, https://purl.org/becyt/ford/3, Management of Cardiovascular Diseases during Pregnancy, Siblings, FOS: Clinical medicine, congenital, Infant, Newborn, Biologie moléculaire, Chagas Disease/congenital/diagnosis/prevention & control/therapy, Infant, Linguistics, Newborn, Transmission (telecommunications), Infectious Disease Transmission, Vertical, Pregnancy Complications, Vertical/prevention & control, Philosophy, Pregnancy Complications, Parasitic, Electrical engineering, Chronic Disease, gyidelines, FOS: Languages and literature, Sciences pharmaceutiques, Pregnant Women, Delivery of Health Care, Public Health Administration, ddc: ddc:618

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
110
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Top 10%
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