Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression
Copyright policy )Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression
Key Points In CML, early alterations of the BMP pathway are involved in the survival of hypersensitive LSCs and the expansion of myeloid progenitors. The leukemic niche provides higher concentrations of BMP2 and BMP4 that fuel a permanent and autonomous pool of leukemic progenitors.
- French National Centre for Scientific Research France
- Cancer Center of Lyon France
- Inserm France
- Hospices Civils de Lyon France
- University of Reims Champagne-Ardenne France
500, Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 4, Models, Biological, Up-Regulation, Cell Line, Tumor, 616, Leukemia, Myeloid, Chronic-Phase, Neoplastic Stem Cells, Tumor Microenvironment, Humans, Stem Cell Niche, Bone Morphogenetic Protein Receptors, Type I, Signal Transduction
500, Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 4, Models, Biological, Up-Regulation, Cell Line, Tumor, 616, Leukemia, Myeloid, Chronic-Phase, Neoplastic Stem Cells, Tumor Microenvironment, Humans, Stem Cell Niche, Bone Morphogenetic Protein Receptors, Type I, Signal Transduction
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