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Neurology
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Neurology
Article . 2015 . Peer-reviewed
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Neurology
Article . 2015
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Teaching Neuro Images : Drug-induced parkinsonism with asymmetrical putaminal DaT binding

Authors: Bridel, Claire; Garibotto, Valentina;

Teaching Neuro Images : Drug-induced parkinsonism with asymmetrical putaminal DaT binding

Abstract

A 64-year-old patient developed shuffling gait and postural instability over 8 months, in parallel to risperidone intake. Examination showed symmetric parkinsonian syndrome and mild left hemiparesis with spasticity, related to right middle cerebral artery stroke 10 years before. Within 1 month of risperdone withdrawal, parkinsonism disappeared, confirming drug-induced etiology. While degenerative parkinsonism is associated with reduction in striatal dopamine transporters binding in absence of structural lesions to basal ganglia, binding in drug-induced parkinsonism is normal.1 In our case, SPECT anomaly was incidental, related to the ischemic sequela (figure).2 This case highlights the importance of brain structural integrity for SPECT interpretation.

Country
Switzerland
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Keywords

Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins, 616.0757, Putamen, Putamen/metabolism, Infarction, Middle Cerebral Artery, Middle Aged, Risperidone, Risperidone/adverse effects, Parkinsonian Disorders, Humans, Infarction, Middle Cerebral Artery/complications, Dopamine Plasma Membrane Transport Proteins/metabolism, Parkinsonian Disorders/chemically induced/diagnostic imaging/metabolism, ddc: ddc:616.0757

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Top 10%
Average
bronze