
pmid: 25987672
A 64-year-old patient developed shuffling gait and postural instability over 8 months, in parallel to risperidone intake. Examination showed symmetric parkinsonian syndrome and mild left hemiparesis with spasticity, related to right middle cerebral artery stroke 10 years before. Within 1 month of risperdone withdrawal, parkinsonism disappeared, confirming drug-induced etiology. While degenerative parkinsonism is associated with reduction in striatal dopamine transporters binding in absence of structural lesions to basal ganglia, binding in drug-induced parkinsonism is normal.1 In our case, SPECT anomaly was incidental, related to the ischemic sequela (figure).2 This case highlights the importance of brain structural integrity for SPECT interpretation.
Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins, 616.0757, Putamen, Putamen/metabolism, Infarction, Middle Cerebral Artery, Middle Aged, Risperidone, Risperidone/adverse effects, Parkinsonian Disorders, Humans, Infarction, Middle Cerebral Artery/complications, Dopamine Plasma Membrane Transport Proteins/metabolism, Parkinsonian Disorders/chemically induced/diagnostic imaging/metabolism, ddc: ddc:616.0757
Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins, 616.0757, Putamen, Putamen/metabolism, Infarction, Middle Cerebral Artery, Middle Aged, Risperidone, Risperidone/adverse effects, Parkinsonian Disorders, Humans, Infarction, Middle Cerebral Artery/complications, Dopamine Plasma Membrane Transport Proteins/metabolism, Parkinsonian Disorders/chemically induced/diagnostic imaging/metabolism, ddc: ddc:616.0757
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