Atlantic salmon (Salmo salar L.) skin contains a novel kininogen and another cysteine proteinase inhibitor
Copyright policy )Atlantic salmon (Salmo salar L.) skin contains a novel kininogen and another cysteine proteinase inhibitor
We describe the purification and characterization of two novel cysteine proteinase inhibitors found in Atlantic salmon skin. One of these, salmon kininogen, has a molecular mass of 52 kDa as determined by matrix‐assisted laser desorption/ionization time‐of‐flight MS, is multiply charged with pI values of 4.0, 4.2 and 4.6 and shows homology to kininogens including the bradykinin motif. The other, salarin, has a molecular weight of 43 kDa, a pI of 5.1 and shows weak homology to cysteine proteinases. Both proteins are N‐ and O‐glycosylated and inhibit papain and ficin but not trypsin.
- University of Helsinki Finland
- Oulu University Hospital Finland
- Norwegian College of Fishery Science Norway
- The Arctic University of Norway Norway
- University of Oulu Finland
Fish Proteins, Repetitive Sequences, Amino Acid, Glycosylation, Sequence Homology, Amino Acid, Kininogens, Molecular Sequence Data, Salmo salar, Cysteine Proteinase Inhibitors, Molecular Weight, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Animals, Amino Acid Sequence, Isoelectric Point, Glycoproteins, Skin
Fish Proteins, Repetitive Sequences, Amino Acid, Glycosylation, Sequence Homology, Amino Acid, Kininogens, Molecular Sequence Data, Salmo salar, Cysteine Proteinase Inhibitors, Molecular Weight, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Animals, Amino Acid Sequence, Isoelectric Point, Glycoproteins, Skin
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