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Microbiology Spectrum
Article . 2022 . Peer-reviewed
License: CC BY
Data sources: Crossref
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Microbiology Spectrum
Article . 2022
Data sources: Europe PubMed Central
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Other literature type . 2022
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Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 31 Aug 2022 English Publisher:American Society for MicrobiologyJournal:Microbiology Spectrum, volume 10 (eissn: 2165-0497, Copyright policy )Funded by:FCT | Novo: Deciphering unexplo..., FCT | Deciphering the role of m..., FCT | MtbcellwallTOFI
Authors: Francisco Olivença; Alexandra Nunes; Rita Macedo; David Pires; Cátia Silveiro; Elsa Anes; Maria Miragaia; +2 Authors

doi: 10.1128/spectrum.00674-22

pmid: 35695524

pmc: PMC9431576

Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing

Abstract

Associations between differential M. tuberculosis beta-lactam phenotypes and preexisting antimycobacterial drug resistance, strain sublineage, or specific mutational patterns were established. Importantly, we reveal that highly drug-resistant isolates of sublineage 4.3.4.2 have an increased susceptibility to beta-lactams compared with other strains.

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Keywords

Carbapenems, Humans, Tuberculosis, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Peptidoglycan, beta-Lactams, Research Article, Anti-Bacterial Agents

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    popularity
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    		 Top 10%
    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Top 10%
Average
Top 10%
Green
gold
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