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Universidade Nova de Lisboa
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198 Projects, page 1 of 40
  • Funder: European Commission Project Code: 101086974
    Overall Budget: 2,492,430 EURFunder Contribution: 2,492,430 EUR

    Inequality is among the most pressing issues of our times. The world has been fast-changing in recent years and the pandemic crisis has put a spotlight on economic inequalities and fragile social safety nets that leave vulnerable communities to bear the brunt of the crisis. The outbreak of a war in Ukraine, with millions of refugees and unforeseen impacts worldwide, will most likely worsen the current situation. It is urgent to tackle inequalities in a comprehensive way, designing public policies grounded on solid knowledge. However, there is still a lack of basic information. Economic growth numbers are published every year, but they do not tell us about how growth is distributed across the population, who gains and who loses from economic policies. Besides, beyond income and wealth, it is also critical to address other dimensions of socioeconomic disparities, such as health, education, gender, or environmental inequalities. Therefore, it is urgent to advance research on inequalities, transfer knowledge to society, and contribute to well-informed, science-based public policies. EQUALNovaERA aims to position Nova School of Business & Economics (Nova SBE) as an international reference in addressing inequalities’ drivers and effects through research, education, and community engagement while contributing to deepening the European Research Area and achieving the Sustainable Development Goals. More specifically it will 1) Create a new Research Group on inequalities; 2) Set up an Institute of Public Policies with the mission of contributing to a more equal and fair society through research, education, and community engagement; 3) Position Nova SBE as an international reference institution in addressing inequalities’ drivers and effects through research and education; 4) Promote science-based awareness on inequalities’ drivers and effects to tackle societal grand challenges; 5) Introduce sustainable structural changes at Nova SBE on and beyond the inequalities’ theme.

  • Funder: European Commission Project Code: 101003374
    Overall Budget: 147,815 EURFunder Contribution: 147,815 EUR

    Currently, we face a global antibiotic resistance crisis aggravated by the slow development of more effective and anti-resistance promoting therapeutical solutions. Protein phosphorylation (PP) has recently emerged as one of the major post-translational modification in bacteria, involved in the regulation of multiple physiological processes. In this MSCA individual fellowship application we aim to bridge the current gap in the field for prokaryotes by unravelling the unknown regulatory role of PP on proteins involved in nitrosative stress (NS) detoxification in the model bacterium E.coli. We propose to examine for the first time both global protein modifications (e.g. phosphoproteomics) under nitrogen species stress, as well as characterize PP in individual proteins involved in NS response. We will construct a network model that reflect the phosphoproteomic changes upon NS in E.coli, that may pave the way for the design of new bacterial targets. Understanding how bacteria respond to the chemical weapons of the human innate system is fundamental to develop efficient therapies. We will pioneer research on the mechanism and the regulation of nitric oxide detoxification proteins already identified as phosphorylated, by analyzing how this modification influences their stability and activity in vitro and in vivo. This project opens up new research paths on bacterial detoxification systems and signalling in general, addressing for the first time the role of PP in these processes. The proposal brings together transversal and scientific skills that will enable the researcher to lead the development of this emerging field and position herself as an expert in the area, and aims at establishing the importance of PP in NO microbial response, a novelty in this field.

  • Funder: European Commission Project Code: 275853
  • Funder: European Commission Project Code: 101113512
    Funder Contribution: 150,000 EUR

    As the popularity of electric vehicles continues to increase, so does the number of batteries reaching the end-of-life that are used to power them being expected that by 2030 it will reach 2 million tons worldwide. On top of this the complexity of battery production results in very high scrap rates (about 10%-30%), especially during production ramp-up, while the scarcity of raw materials in Europe are intensifying EU regulations to localize supply chains and safeguard critical raw materials. It is evident that there is strong need to increase sustainability in the batteries value chain and contributions may come from improving both their lifetime and recyclability of the cell components. In EXCELL it is proposed to prove a new concept for batteries separators based on a 100% natural cellulose nanocomposite with tuneable mesopores obtained by a mixture of nanofibers and cellulose nanocrystals. Additionally, these new separators will be suitable for the incorporation of sensing elements that will enable the new generation of smart battery cells. EXCELL will follow the outputs of NEWFUN-StG where it was demonstrated that cellulose based ionic conductive materials are possible to be recycled and reused while maintaining the electrochemical performance. The PI’s team has also demonstrated that cellulose nanocrystals are able to create mesoporous ionic conductive channels that can be tunned to specific alkali ions but proper functionalization of the crystals’ surface. EXCELL will now demonstrate the synergic effect of combining both to form hierarchical mesoporous membranes exhibiting a unique set of characteristics that can meet those ones expected for an “ideal” separator. EXCELL will follow an approach of validating the new separator concept and then implement a IPR consolidation and a business case to attract the attention of battery market stakeholders on new opportunities for cell components based on abundant natural resources that are recyclable/biodegradable.

  • Funder: European Commission Project Code: 101003441
    Overall Budget: 147,815 EURFunder Contribution: 147,815 EUR

    The World Health Organization recently added Acinetobacter baumannii at the top of the priority list of emerging and critical pathogens, against which the number of effective antibiotics is alarmingly low. I propose to find novel antimicrobial targets for A. baumannii by discovering haem related systems that contribute to its survival. Bioinformatics will be used as a powerful tool to explore A. baumannii haem metabolism-related genes. The role of these genes will be tested through microbiology and biochemistry approaches, and their contribution to virulence will be analysed in host-pathogen interaction assays. This multidisciplinary research programme will boost my scientific skills and act as a pipeline to launch my career as an independent researcher. Furthermore, this proposal has the added value of including a custom-made training programme on leadership, management, dissemination and outreach activities. Hence, “AgainstResistance” will be the ideal framework to enhance my competences, maturity and independence as a competitive researcher, and crucial to boost my career prospects as a future group leader in the field of antimicrobial resistance, which is one of the critical current and future health challenges. The proposal will make a real difference in European excellence and competitiveness by materialising its leadership and expertise in multidrug resistance of human pathogens.

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